TEAM

Educational qualifications

• Ph.D., Graduate Institute of Medical Science, Kaohsiung Medical College, Taiwan.

Experience

1. Current-Professor, Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Taiwan.
2. Current-Attending physician, Division of Hematology/Oncology,Department of Pediatrics, Kaohsiung Medical University Hospital,Taiwan.
3. Current-President, Taiwan Society of Thrombosis and Hemostasis,Taiwan.
4. Current-Executive Director, Taiwan Society of Gene Therapy,Taiwan.
5. Past-Director, Division of Hematology/Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital, Taiwan.
6. Past-Director, Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Taiwan.
7. Past-Director, Center of Applied Genomics, Kaohsiung Medical University, Taiwan.

Areas of expertise

1. Pediatric Medicine
2. Gene Therapy
3. Bone Marrow Transplantation
4. Blood, coagulation and thrombosis medicine

Professional writings

• Shyh-Shin Chiou, Ching-Yeh Lin, Te-Fu Weng, Jiaan-Der Wang, Sheng-Chieh Chou, Ching-Tien Peng, Pei-Chin Lin, Yu-Mei Liao, Leanne Lai*,Ming-Ching Shen*, Taiwan Society of Thrombosis, Hemostasis (TSTH) Study Group. Evaluating the Effectiveness of Prophylactic Strategies for Hemophilia A Management: A Real-World, Longitudinal Observational Study. Drugs Real World Outcomes. 2024 Dec;11(4):711-723 (first author)
• Shyh-Shin Chiou, Te-Fu Weng, Jiaan-Der Wang*. Patient and Caregiver Preferences for Hemophilia A Treatment in Taiwan: A Discrete Choice Experiment. VALUE HEALTH REG ISSUES. 2024 Aug 27:45:101035.(first author).
• Hsi-Che Liu, Ying-Jung Huang, Tang-Her Jaing, Kang-Hsi Wu, Shih-Hsiang Chen, Shih-Chung Wang, Ting-Chi Yeh, Chih-Cheng Hsiao, Te-Kau Chang, Hsiu-Ju Yen, Fang-Liang Huang, Pei-Chin Lin, Jen-Yin Hou, Jiunn-Ming Sheen, Yu-Mei Liao, Tsung-Yen Chang, Yu-Chieh Chen,Shyh-Shin Chiou, Chao-Ping Yang, Ching-Hon Pui, Der-Cherng Liang,Lee-Yung Shih. Refining risk stratification in paediatric B-acute lymphoblastic leukaemia: Combining IKZF1plus and Day 15 MRD positivity. Br J Haematol. 2024 Apr;204(4):1344-1353.
• Wan-Yi Hsu, Li-Ting Wang, Pei-Chin Lin, Yu-Mei Liao, Shih-Hsien Hsu*,Shyh-Shin Chiou*. Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis. Antioxidants (Basel). 2024 Mar 29;13(4):424.(co-corresponding author)
• Yu-Mei Liao, Shih-Hsien Hsu*, Shyh-Shin Chiou*. Harnessing the Transcriptional Signatures of CAR-T-Cells and Leukemia/Lymphoma Using Single-Cell Sequencing Technologies. Int J Mol Sci. 2024 Feb;25(4): 2416. (co-corresponding author)
• Wan-Yi Hsu, Shyh-Shin Chiou, Pei-Chin Lin, Yu-Mei Liao, Chung-Yu Yeh, Yu-Hsin Tseng. Prediction of miRNA‑mRNA network regulating the migration ability of cytarabine‑resistant HL60 cells. Biomed Rep. 2023 Dec 13;20(2):20.
• Li-Teh Liu, Shyh-Shin Chiou, Po-Chih Chen, Chun-Hong Chen, Ping-Chang Lin, Ching-Yi Tsai, Wan-Long Chuang, Shang-Jyh Hwang, Inn-Wen Chong, Jih-Jin Tsai. Epidemiology and analysis of SARS-CoV-2 Omicron subvariants BA.1 and 2 in Taiwan. Sci Rep. 2023 Oct 3;13(1):16583.
• Ming-Ching Shen, Sheng-Chieh Chou, Shyh-Shin Chiou, Pei-Chin Lin, Yeu-Chin Chen, Hsuan-Yu Lin, Yang-Cheng Lee, Cih-En Huang, Te-Fu Weng, Ting-Huan Huang, Chih-Yuan Chung, Jiann-Shiuh Chen, Shu-Huey Chen, Shin-Nan Cheng, Chih-Cheng Hsiao, Yen-Min Huang, Shih-Hsiang Chen, Yuan-Bin Yu, Shih-Chiang Lin, Ching-Yeh Lin, Ching-Tien Peng, Jiaan-Der Wang; Taiwan Society of Thrombosis and Hemostasis study group. Efficacy, safety and cost of emicizumab prophylaxis in haemophilia A patients with inhibitors: A nationwide observational study in Taiwan. Haemophilia. 2023 Nov;29(6):1499-1508.
• Pei-Chin Lin, Wan-Yi Hsu, Po-Yi Lee, Shih-Hsien Hsu*, Shyh-Shin Chiou*. Insights into Hepatocellular Carcinoma in Patients with Thalassemia: From Pathophysiology to Novel Therapies. Int. J. Mol. Sci. 2023, August, 24(16), 12654; https://doi.org/10.3390/ijms241612654. (co- corresponding author)
• Kai-Ting Chuang, Shyh-Shin Chiou*, Shih-Hsien* Hsu. Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial–Mesenchymal Transition. Cancers 2023 June 25,15(13), 3338. (co-corresponding author)
• Li-Ting Wang, Shen-Nien Wang, Shyh-Shin Chiou, Jhih-Peng Tsai, Chee-Yin Chai, Li-Wen Tseng, Jin-Ching Lee, Ming-Hong Lin, Shau-Ku Huang, Shih-Hsien. HsuHCV Core Protein-ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression. Adv Sci (Weinh). 2023 Jun 14;e2300644. doi:10.1002/advs.202300644
• Chia-Yau Chang, Shyh-Shin Chiou, Te-Fu Weng, Pei-Chin Lin, Shiue-Wei Lai, Chen-Hua Tsai, Yen-Lin Liu, Jung-Tzu Ku, Yu-Mei Liao, Jia-Ruey Tsai, Shu-Hsia Hu, Chao-Neng Cheng, Yeu-Chin Chen. Clinical Predictors and Prediction Models for rFVIII-Fc Half Life in Real-World People with Severe Hemophilia A. J Clin Med. 2023 Mar 13;12(6):2207.
• Johnny Mahlangu, Radoslaw Kaczmarek, Annette von Drygalski, Susan Shapiro, Sheng-Chieh Chou, Margareth C Ozelo, Gili Kenet, Flora Peyvandi, Michael Wang, Bella Madan, Nigel S Key, Michael Laffan, Amy L Dunn, Jane Mason, Doris V Quon, Emily Symington, Andrew D Leavitt, Johannes Oldenburg, Hervé Chambost, Mark T Reding, Kala Jayaram, Hua Yu, Reena Mahajan, Konstantia-Maria Chavele, Divya B Reddy, Joshua Henshaw, Tara M Robinson, Wing Yen Wong, Steven W Pipe; GENEr8-1 Trial Group. Two-Year Outcomes of Valoctocogene Roxaparvovec Therapy for Hemophilia A. N Engl J Med. 2023 Feb 23;388(8):694-705.
• Miyuki Hsing-Chun Hsieh, Shyh-Shin Chiou #1 , Tzu-Chi Liao, Shi-Jie Lai, Edward Chia-Cheng Lai. Effectiveness of Prophylactic Coagulation Factor Replacement Therapy in Patients with Severe Hemophilia A in Taiwan - A Population-Based Study. Clin Epidemiol. 2022 Dec 13;14:1501-1510. (co-first author)
• Ting-Huan Huang MD, Giun-Yi Hung MD, Te-Fu Weng MD, Fu-Mien Wang MD, Chih-Ying Lee MD, Dong-Tsamn Lin MD, Bow-Wen Chen MD, Kai-Hsin Lin MD, Kang-Hsi Wu MD, Hsi-Che Liu MD, Jiann-Shiuh Chen MD, Shiann-Tarng Jou MD, Jen-Yin Hou MD, Yung-Li Yang MD, Shih-Hsiang Chen MD, Hsiu-Hao Chang MD, Shyh-Shin Chiou MD, Pei-Chin Lin MD, Rong-Long Chen MD, Chih-Cheng Hsiao MD, Hsiu-Ju Yen MD,Chao-Ping Yang MD, Te-Kau Chang MD, Meng-Yao Lu MD, Chao-Neng Cheng MD, Jiunn-Ming Sheen MD, Yu-Mei Liao MD, Min-Yu Su MD,Ting-Chi Yeh MD, Taiwan Pediatric Oncology Group. Surgical treatment confers prognostic significance in pediatric malignant mediastinal germ cell tumors. Cancer. 2022 Dec, 1;128(23):4139-4149.
• Ming-Ching Shen, Shyh-Shin Chiou, Sheng-Chieh Chou, Te-Fu Weng,Ching-Yeh Lin, Jiaan-Der Wang, Shou-Wu Lee, Ching-Tien Peng. Prevalence of non-Alcoholic Fatty Liver Disease and Associated Factors in Patients with Moderate or Severe Hemophilia: A Multicenter-Based Study. 2022 Sep. Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221128294.
• Li-Wen Chiu, Ting-Ting Yang, Shyh-Shin Chiou, Wei-Cheng Fang, Cheng-Che E Lan. Refractory oral ulcers. Pediatr Dermatol. 2022 Jul;39(4):625-627. doi: 10.1111/pde.14974.
• Li-Ting Wang, Kwei-Yan Liu, Shen-Nien Wang, Ming-Hong Lin, Yu-Mei Liao, Pei-Chin Lin, Shau-Ku Huang, Shih-Hsien Hsu*, Shyh-Shin Chiou*. Aryl hydrocarbon receptor-kynurenine axis promotes oncogenic activity in BCP-ALL. Cell Biol Toxicol. 2022 Jun 10. doi: 10.1007/s10565-022-09734-0. Online ahead of print. (corresponding author)
• Li-Min Wu, Shyh-Shin Chiou, Pei-Chin Lin, Yu Mei Liao, Hsiu-Lan Su.Decisional conflicts, anxiety, and perceptions of shared decision-making in cancer treatment trajectory among adolescents with cancer: A longitudinal study. J Nurs Scholarsh. 2022 Mar 3. doi: 10.1111/jnu.12772.
• Hsiao HH, Liu YC, Wang HC, Du JS, Tang SH, Yeh TJ, Hsieh CY, Gau YC, Ke YL, Chuang TM, Hsiao CE, Yen CH, Cho SF, Hsiao SY, Chiou SS, Lin SY, Hsu CM, Lu PL. Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. J Formos Med Assoc. 2022 May 12;S0929-6646(22)00155-3. doi: 10.1016/j.jfma.2022.04.011.
• Ozelo, M. C., Mahlangu, J., Pasi, K. J., Giermasz, A., Leavitt, A. D., Laffan, M., ... & Kim, B. (2022). Valoctocogene roxaparvovec gene therapy for hemophilia A. New England Journal of Medicine, 386(11),1013-1025.